High Throughput Experimentation (HTE)
The HTE@ETH lab has two liquid handling robotic platforms to prepare catalyst formulations and test them at elevated temperatures and pressures under strictly anaerobic conditions. Up to 96 experiments can be carried out simultaneously on both heterogeneous and homogeneous catalysts and a gas-uptake parallel reactor operated inside a glovebox allows for the reaction optimization studies and mechanistic investigations.
High-Throughput Catalyst Screening
A. Fedorov,* H.-J. Liu, H.-K. Lo, C. Copéret, Silica-Supported Cu Nanoparticle Catalysts for Alkyne Semihydrogenation: Effect of Ligands on Rates and Selectivity, J. Am. Chem. Soc. 2016, 138, 16502‑16507.
Reaction Optimization and Catalyst Testing
D. P. Estes, C. Bittner, Ò. Àrias, M. Casey, A. Fedorov, M. Tamm,* C. Copéret,* Alkyne Metathesis with Silica-Supported and Molecular Catalysts at Parts-per-Million Loadings, Angew. Chem. Int. Ed. 2016, 55, 13960‑13964. Frontispiece, DOI: 10.1002/anie.201684561.
M. Pucino, V. Mougel, R. Schowner, A. Fedorov, M. R. Buchmeiser,* C. Copéret,* Cationic Silica-Supported N-Heterocyclic Carbene Tungsten Oxo Alkylidene Sites: Highly Active and Stable Catalysts for Olefin Metathesis, Angew. Chem. Int. Ed. 2016, 55, 4300‑4302.
H.-J. Liu, I. C. Cai, A. Fedorov, M. S. Ziegler, C. Copéret,* T. Don Tilley,* Tricoordinate Organochromium(III) Complexes Supported by a Bulky Silylamido Ligand Produce Ultra-High-Molecular Weight Polyethylene in the Absence of Activators, Helv. Chim. Acta 2016, 99, 859‑867.
P. S. Engl, A. Fedorov, C. Copéret, A. Togni,* N-Trifluoromethyl NHC Ligands Provide Selective Ruthenium Metathesis Catalysts, Organometallics, 2016, 35, 887‑893.